Tag Archives: Geniverse

Virtual CRISPR-like techniques engage students in editing dragon DNA

The CRISPR gene editing technique is faster, cheaper, and more accurate than past methods of editing DNA. And it’s creating a huge buzz in the world of science and medical research. By precisely removing, adding, or altering part of the genome, CRISPR enables geneticists to target and edit genes that are associated with genetic diseases—without affecting other areas of the genome, a major drawback of previous approaches.

A recent story (CRISPR, 5 ways) includes a video, produced by Wired magazine, in which a biology professor at NYU explains CRISPR to a seven-year-old, a high school student, a college student, a graduate student, and an expert scientist in the field of genetics. The conversations range from genomes to the value of basic research.

In the final conversation with the expert scientist, the focus shifts to the level of DNA and genome engineering. Scientists who use CRISPR must understand the underlying mechanisms by which the genes affect particular genetic traits and disorders. They’re able to learn about the composition and functionality of genes from model species they study and apply what they’ve learned to another target species (e.g., the mouse is a model species for human genetic disease).

We’ve created an online learning environment that allows middle and high school students to do the same.

Geniventure, dragon genetics software

Geniventure, the next generation of our popular dragon genetics software Geniverse, places students in a virtual underground lab where they perform genetic experiments with drakes, the model organism for dragons. There is real biology behind the mythical drake and dragon genes and traits, which have been carefully compiled from the actual genes and associated traits of the anole lizard, mouse, fruit fly, zebrafish, and other model species used to study genetics. The genes that affect horns, wings, color, and other drake traits are genes that are involved in the development and functioning of similar traits in real organisms.

In our Geniventure game, students zoom into a drake’s genes, see the actual DNA code behind them, and manipulate the resulting proteins as the proteins do the work of producing traits. The first set of protein-based challenges using this new interface revolves around scale color (modeled after the same genes for human skin color) and allows students to edit the genes of an albino drake. After working with the proteins that produce melanin and discovering a broken enzyme that results in an albino drake, students enter the nucleus of the cell to change the drake’s genes (and DNA) from producing the broken enzyme so that it can create the functional protein, ultimately generating a drake with color distributed throughout its scales.

From albino to charcoal (right). In the protein-level challenges, students can view the starting state of their drake’s scale color (Albino), the current state (Lava), and the target state (Charcoal). The Start and Target views also display the distribution of color throughout the drake’s scale cells.

Proteins in action. In the Geniventure Zoom Room, students experiment with proteins and discover how they influence the color of the drake. Students are tasked with manipulating the proteins of an albino drake to restore color to its scales.

Inside the nucleus. In some challenges, students are unable to work with the proteins directly. Instead, they must enter the nucleus where they can alter the drake’s alleles to create the proteins needed to reach the target color.

Making this protein-based link from DNA to trait is critical for students’ ability to make sense of patterns between genes and traits— for example, dominant vs. recessive versions of genes— and to apply the same logic to other genetic phenomena. Through Geniventure, students are able to transfer their experience of editing genes and working with proteins in drakes to an understanding of how scientists are using CRISPR and other techniques.

Our goal is to help students better understand modern science, including biotechnology advances such as CRISPR, to make science engaging and relevant, so students can ultimately envision themselves as future scientists.

Why dragons?

Breeding virtual dragons is all in a day’s work in biology classrooms using Geniverse, our free, web-based genetics software. Although Geniverse is a game-like environment, it’s far more than child’s play. Indeed, students dive into genetics on a quest to heal a beloved dragon. Students use a model species (drakes) to explore the fundamental mechanisms of heredity and genetic diseases and get a taste of careers in genetics. (Drakes are essentially a smaller version of a dragon, and are a model species in much the same way as the mouse is a model species for human genetic disease.)

But why did we choose dragons and drakes? To start, they are just plain fun! And since they’re mythical, we can bring together into one animal any and all real-world genes we’d like to teach with—without having to be restricted to a specific species’ genome. So, while our dragons and drakes are fantastical, their genes are very much real, gathered from mice, fruit flies, lizards, and other organisms we study in laboratories all over the world. When students learn genetics with Geniverse, they’ll encounter the genes again, should they venture into a real genetics lab later in life.

Students begin their Geniverse adventure as a student in the Drake Breeder’s Guild, where they move through four levels of progressively more difficult genetics challenges and unlock new chapters of the narrative. Try Geniverse now and learn how fun (and educational) dragons can be!

The real genes of Geniverse

Did you know that while dragons and their model species drakes are fictional and fanciful, the genetics of these virtual Geniverse creatures is based firmly on the real-world genetics of model organisms?

The drake genes and traits have been carefully compiled from the actual genes and associated traits of the anole lizard, mouse, fruit fly, zebrafish, and other model species. The genes for forelimbs, wings, color, and other drake traits are genes that are involved in the development of those traits in real organisms. There’s real biology behind the Geniverse narrative as well: the disease that plagues our hero’s dragon friend is modeled on a rare human metabolic disorder, ornithine transcarbamylase (OTC) deficiency. In fact, since the genes of humans are similar to the genes of the model organisms we use in real life—that’s why we can learn so much about human genetics from them—the genes of the Geniverse drakes are quite similar to human genes.

In addition, the interactive models that students use to conduct virtual experiments in Geniverse are powered by genetics programming that accurately simulates real-life patterns of inheritance in humans as well as model organisms. Students who learn with Geniverse are learning to analyze experimental results that would be obtained from these genes in a laboratory.

Nomenclature Genomic Location
Symbol w Chromosome 1
Name wingless Linkage map 70 cM
Species Dracomimus familiaris Genome coordinates unknown

 

Summary information
Phenotype: The wingless gene affects wing development in drakes. Homozygotes for the wingless allele (w/w) lack externally visible wings entirely. The skeleton of wingless drakes has a vestigial dorsal shoulder and a remnant of the proximal wing bone. Note: This gene and phenotype are taken from the fruit fly, d. Melanogaster, and the human correlate gene, called Wnt1, is 80% similar to the wingless DNA sequence.
   
W/W or W/w w/w

 

Alleles and Phenotypes
Allele Summary
W Presumptive wild-type allele
w Recessive allele
Genotype Phenotype
W/W Normal wings
W/w Normal wings
w/w wingless

 

Nomenclature Genomic Location
Symbol Wnt1 Chromosome 1
Name Proto-oncogene Wnt-1 Linkage map unknown
Species Dracomimus familiaris Genome Coordinates 1: 70 Mbp

At the University of Massachusetts at Amherst, students are utilizing bioinformatics tools to build new drake genes, mutant alleles, and phenotypes based on investigations of the scientific literature. In an exploration of multiple genetic mechanisms, students have created drakes whose genotypes give rise to deafness and dwarfism, cancer and cold tolerance, polydactyly, and the ability to spit spider silk. We’re thrilled to see these additions to our drake genome!

5 Reasons to Vote in STEM For All Video Showcase

We’re thrilled to present five videos in the National Science Foundation STEM for All Video Showcase from May 17 to 23! We invite you to view the videos and join the conversation about the latest research in STEM and computer science teaching and learning. Please vote for our videos through Facebook, Twitter, or email!

CODAPCODAP

Data are everywhere, except in the classroom! Learn how our Common Online Data Analysis Platform (CODAP) is bringing more rich experiences with data to more teachers and students.

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Teaching TeamworkTeaching Teamwork

Collaboration is highly valued in the 21st century workplace. Our Teaching Teamwork project is measuring how effectively electronics students work in teams.

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GeniverseGeniConnect & GeniGUIDE

Geniverse engages students in exploring heredity and genetics by breeding virtual dragons. GeniConnect connects afterschool students with biotech scientists to play Geniverse together. In GeniGUIDE, we’re adding an intelligent tutoring system to Geniverse, supporting students and relaying information to the most intelligent tutor in the room – the teacher.

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Teaching Environmental Sustainability with Model My WatershedTeaching Environmental Sustainability
with Model My Watershed

Teaching Environmental Sustainability with Model My Watershed is developing place-based, problem-based, hands-on set tools aligned to NGSS to promote geospatial literacy and systems thinking for middle and high school students.

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GRASPGRASP

GRASP (Gesture Augmented Simulations for Supporting Explanations) is investigating how middle school students use body movement to build deeper reasoning about critical science concepts.

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Digital gaming will connect afterschool students with biotech mentors

Our nation’s future competitiveness and our citizens’ overall STEM literacy rely on our efforts to forge connections between the future workforce and the world of emerging STEM careers. Biotechnology, and genetics in particular, are rapidly advancing areas that will offer new jobs across the spectrum from technicians to scientists. A new $1.2 million National Science Foundation-funded project at the Concord Consortium will use Geniverse, an immersive digital game where students put genetics knowledge into action as they breed dragons, to help connect underserved students with local biotechnology professionals to strengthen student awareness of STEM careers.

East End House Students

Students from East End House enjoy collaborating on computer-based science activities.

Geniverse is our free, web-based software designed for high school biology that engages students in exploring heredity and genetics by breeding and studying virtual dragons. This game-like software allows students to undertake genetics experimentation with results that closely mimic real-world genetics. The new GeniConnect project will extend the gaming aspects of Geniverse and revise the content to more fully target middle school biology, introducing Geniverse to the afterschool environment.

The three-year GeniConnect project will develop and research a coherent series of student experiences in biotechnology and genetics involving game-based learning, industry mentoring, and hands-on laboratory work. Industry professionals from Biogen, Monsanto, and other firms will mentor afterschool students at East End House, a community center in East Cambridge, Massachusetts.

With researchers from Purdue University, we’ll explore how an immersive game and a connection to a real scientist can increase STEM knowledge, motivation, and career awareness of underserved youth. We will also develop and research a scalable model for STEM industry/afterschool partnerships, and produce a STEM Partnership Toolkit for the development of robust, educationally sound partnerships among industry professionals and afterschool programs. The Toolkit will be distributed to approximately 500 community-based organizations and afterschool programs nationally that are member organizations of the Alliance for Strong Families and Communities.

Geniverse Narrative

Beautiful graphics designed by FableVision Studios engage students in a compelling narrative. Students follow the arduous journey of their heroic character and suffering dragon to the Drake Breeder’s Guild.

Geniverse Lab

Students are welcomed into the Drake Breeder’s Guild where they will learn the tricks of the genetic trade. (Drakes are a model species that can help solve genetic mysteries in dragons, in much the same way as the mouse is a model species for human genetic disease.) Students are engaging in an authentic, experiment-driven approach to biology—in a fantastical world.

Classrooms on fire…with dragon genetics!

No smoke and mirrors here: dragons are getting kids all fired up about genetics. Geniverse software engages students with compelling reasons to solve genetics problems. As they rise through the ranks of the Drake Breeders Guild, students win stars and quills for efficient experimentation and for using their own experimental results as evidence for their scientific claims. Watch how students are learning genetics while having fun—using Geniverse! Want to get your students fired up about genetics, too? Sign up to use Geniverse in your classroom next year.